Lack of a heart break

No one, not even my sister, gets everything he or she wants. She apparently wanted to marry into the Medici family for reasons I'm sure you can guess, if you've been keeping up with my stories about the greedy old bitch.

When the family realized that she was unable to love, she was rejected. She made sure that they never produced an heir, and that's why their lineage died out in the 17th century.